Table 1 Morphometric analysis of glomeruli and proximal tubule cells.

From: Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease

 

Control

VHLΔPT

con/STZ

VHLΔPT/ STZ

Glomerular morphometry

Bowman capsule area in µm2

5387 ± 70

5588 ± 189

6378 ± 307*

6793 ± 324*

Tuft area in µm2

4276 ± 20

4443 ± 134

5332 ± 332**

5635 ± 346*

capillary area/ tuft area

0.41 ± 0.01

0.45 ± 0.01*

0.51 ± 0.04*

0.52 ± 0.04*

GBM thickness in nm

109.2 ± 9.9

133.1 ± 10.8*

136.0 ± 12.6*

143.2 ± 13.1*

Podocyte foot processes per GMB length in n/µm

3.24 ± 0.24

3.19 ± 0.12

2.94 ± 0.15*

3.18 ± 0.19

Tubular morphometry

Epithelial height in µm

4.7 ± 0.18

5.78 ± 0.84*

5.88 ± 0.85*

5.65 ± 0.58*

Basement membrane height in nm

80.4 ± 13.5

125.8 ± 16.3*

115.2 ± 35.4

124.8 ± 9.4*

Microvilli length in µm

1.6 ± 0.26

1.5 ± 0.18

1.4 ± 0.14

1.4 ± 0.13

Invagination/surface in n/µm

23.6 ± 4.1

24.2 ± 3.7

28.6 ± 2.2

29.4 ± 6.5

  1. Quantitative analysis of light and electron microscopy of areas from Bowman´s capsule and tuft, capillary per tuft, and glomerular basement membrane (GBM) thickness, podocyte foot processes per GBM length, proximal tubule S1/2 epithelial height, tubular basement membrane thickness, microvilli length and the number of invaginations per cell surface. Arithmetic means ± SEM of n = 6 per group.
  2. *P < 0.05, **P < 0.01.
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