Fig. 2: Caspase 3/7 activity in C2C12 myoblasts exposed to simvastatin with or without CB1 drugs. | Cell Death & Disease

Fig. 2: Caspase 3/7 activity in C2C12 myoblasts exposed to simvastatin with or without CB1 drugs.

From: Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin

Fig. 2

A Measurement caspase 3/7 activation in myoblasts exposed to simvastatin (30 µM) for 24 h in the presence or absence of selective CB1 agonists (ACEA 1 µM or noladin ether 1 µM) or antagonists (rimonabant 1 µM or AM251 1 µM). Each bar is the mean ± S.E.M. from 5 to 6 independent biological samples. ** = p ≤ 0.01 versus the veh group; ± = p ≤ 0.05 versus the group treated with simvastatin alone (B) Representative images captured using bright-field light microscopy (10x magnification) showing the effect of simvastatin (24 h) in myoblasts in the presence of ACEA or rimonabant.

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