Fig. 1: CRTAC1 is strongly associated with the response to chemotherapy in non-small cell lung cancer (NSCLC). | Cell Death & Disease

Fig. 1: CRTAC1 is strongly associated with the response to chemotherapy in non-small cell lung cancer (NSCLC).

From: CRTAC1 enhances the chemosensitivity of non-small cell lung cancer to cisplatin by eliciting RyR-mediated calcium release and inhibiting Akt1 expression

Fig. 1: CRTAC1 is strongly associated with the response to chemotherapy in non-small cell lung cancer (NSCLC).The alternative text for this image may have been generated using AI.

A The overall survival of 98 patients with NSCLC treated with cisplatin-based chemotherapy in the GEO datasets was positively correlated with CRTAC1 expression levels. B The expression level of CRTAC1 protein in different NSCLC cell lines was detected by western blotting. The numbers below represent the ratio of the gray value of the CRTAC1 protein band relative to that of internal control. The H1299, H226, H520, and HCC827 cell lines were classified into the CRTAC1 low expression group, whereas A549, H2170, and H1975 cells were in the high expression group. C The viability of NSCLC cell lines treated with 0–40 µM cisplatin for 48 h was detected by the ATP assay, and the cisplatin IC50 values of different NSCLC cell lines were calculated. The IC50 for cisplatin was lower in the high CRTAC1 expression group than in the low expression group. D Pearson correlation analysis showed a significant negative correlation between the expression of CRTAC1 protein and the IC50 value of cisplatin in NSCLC cell lines. Low: low expression; High: high expression; P < 0.05 indicates a significant difference; r, correlation coefficient with (−) indicating a negative correlation.

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