Fig. 8: Laminin signaling pathway in control and DMD muscle samples.

A Hierarchical plot shows the inferred intercellular communication network for laminin signaling. This plot consists of two parts: Left and right portions highlight the autocrine and paracrine signaling to FAPs, regenerative fibers, satellite cells, and adipocytes and to the other clusters identified, respectively. Solid and open circles represent the source and target, respectively. Circle sizes are proportional to the number of cells in each cell group and edge width represents the communication probability. Edge colors are consistent with the signaling source. B Heatmap shows the relative importance of each cell group based on the computed network centrality measures of the laminin signaling network in control samples. C The hierarchical plot shows the inferred intercellular communication network for laminin signaling in DMD samples. D Heatmap shows the relative importance of each cell group based on the computed network centrality measures of the laminin signaling network in control samples. E Chord plot displaying intercellular communication network for laminin signaling in controls. F Chord plot displaying intercellular communication network for laminin signaling in DMD. G Relative contribution of each ligand-receptor pair to the overall communication network of a laminin signalling pathway in control samples, which is the ratio of the total communication probability of the inferred network of each ligand-receptor pair to that of the laminin pathway. H Relative contribution of each ligand-receptor pair to the overall communication network of a laminin signaling pathway in DMD samples. I Violin plot showing the expression distribution of signaling genes involved in the inferred laminin signaling.