Fig. 7: The protective effect of 20C on mitochondrial morphology. | Cell Death & Disease

Fig. 7: The protective effect of 20C on mitochondrial morphology.

From: A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson’s disease

Fig. 7: The protective effect of 20C on mitochondrial morphology.The alternative text for this image may have been generated using AI.

A Representative TEM photomicrographs (left) and percentage (right) of intact mitochondrial. B Representative TEM photomicrographs (left) and percentage (right) of swollen mitochondrial. C Representative TEM photomicrographs (left) and percentage (right) of damaged mitochondrial. D Representative TEM photomicrographs (left) and percentage (right) of degenerating mitochondria. Scale bar = 200 nm. E Ultrastructure of the mitochondria in SNc. The red spot in control represents the damaged mitochondria. Scale bar = 0.5 µm. F The proportion of mitochondria with different forms. G Box plot graph representing total mitochondrial morphological parameters. H–N Histograms for each morphological parameter of mitochondria: area, perimeter, area/perimeter ratio, circularity, roundness, aspect ratio, and Feret diameter. O Photomicrographs in green demonstrate changes in mitochondrial morphologies in control and 20C group; Photomicrographs in white are the enlarged images of the designated square boxes in the green photomicrographs. Mitochondria in 20C existed as an interconnected tubular network, whereas mitochondria in control appeared as swollen tubes and fragmentation (short separate tubes & swollen tubes). P Histograms for each morphological form factor presented in (O). (Error bars are represented as SEM of mean values, n = 3. *p < 0.05, ***p < 0.001 vs. the control group).

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