Fig. 3: β2-AR expression in HNSCC mouse model.
From: β2-AR inhibition enhances EGFR antibody efficacy hampering the oxidative stress response machinery
a Immunohistochemistry assay on mice tongues engrafted with UMSCC 103 for the β2-AR detection. This receptor was highly expressed in the untreated, while the CTX or ICI treatment induced its strong down-regulation. The inhibitory effect is more evident if we combine the drugs. b Western Blot analysis of the β2-AR modulation in cancer cells collected from the tumor bulk. The treatment of ICI and CTX significantly reduced the adrenoceptor expression (*P ≤ 0.05 vs. CTR).
