Fig. 3: Enhanced OTUD4 alleviates emphysema by reducing cell apoptosis.
From: CSE reduces OTUD4 triggering lung epithelial cell apoptosis via PAI-1 degradation
A Western blot to detect the expression of OTUD4 protein in the lung tissue of mice. B Representative results of IHC (400×) for OTUD4 in different groups were shown. C Histological changes of lung sections were shown with H&E (200×) staining. Morphometric measurements of MLI (μm) and DI (%) were plotted. D The expression of apoptotic protein including BCL2, Bax and cleaved caspase 3 were detected in the lung tissue of mice. E Apoptotic nuclei were detected by TUNEL staining (400×) in the lung tissue of mice. Lenti-EV: empty vector, Lenti-OTUD4: OTUD4 overexpression; Data were shown as mean ± SD of three independent experiments. *P < 0.05.
