Fig. 1: Diversity and abundance analysis based on untargeted LC-MS and GC-MS analysis.

a Principal component analysis of MCAO and sham groups. b Volcano plot comparing MCAO vs. sham groups; blue: downregulated, red: upregulated in MCAO group. c Heatmap of differentially accumulated metabolites in MCAO vs. sham groups. d Pathways enriched for metabolic variations after MCAO. e Kyoto Encyclopedia of Genes and Genomes pathway bubble chart of differentially accumulated metabolites for MCAO vs sham groups. GC-MS gas chromatography-mass spectrometry, LC-MS liquid chromatography-mass spectrometry, MCAO middle cerebral artery occlusion.