Fig. 3: Expression and drug sensitivity of core ferroptosis-related genes in the context of RCC. | Cell Death & Disease

Fig. 3: Expression and drug sensitivity of core ferroptosis-related genes in the context of RCC.

From: Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases

Fig. 3

A Expression of GPX4, SLC7A11, ACSL4, and AIFM2 in different kidney cancer tissues and normal tissues was analyzed using the R package ggplot2 based on the TCGA and GTEx databases. B The correlation between drug sensitivity and the expression of SLC7A11, AIFM2, and GPX4 was analyzed using the Gene Set Cancer Analysis (GSCA) database. C The relationship between sorafenib and four ferroptosis-related genes in RCC samples. D The effect of expression of four ferroptosis-related genes on the half-maximal inhibitory concentration (IC50) value of sorafenib in RCC samples. The predicted chemotherapeutic response of each sample was analyzed using the R package pRRophetic according to the Genomics of Drug Sensitivity in Cancer (GDSC) database. The IC50 of the samples was assessed by ridge regression. The Wilcox test was used to compare and determine the significant difference between two different groups.

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