Table 1 Drugs and other compounds that regulate ADCD.

RCD

–

Normal autophagy

[25, 27]

Bax/Bak KO

–

[26]

SH003

Activates ATF4 and inhibit G9a

[34]

Kaempferol

Activates IRE1-JNK-CHOP and inhibits G9a

[35]

Tunicamycin

Promotes ceramide synthesis through GBA1 action

[40]

Resveratrol

Activates GBA1 to promote ceramide synthesis

[65]

THC

Promotes dihydroceramide accumulation in lysosomes, which leads to LMP

[68]

ABTL0812

Promotes dihydroceramide accumulation, which activates the ATF4-DDIT3-TRIB3 pathway

[71]

Loperamide

Activates the ATF4-FAM134B axis and TEX264, leads to lipid accumulation in lysosomes and lipid ROS production

ER-phagy

[36, 47]

Z36

Activates FAM134B and the UPR

[37]

Sorafenib

Activates FAM134B

[38]

Activate smARF

smARF bind to parkin to promote mitophagy

Mitophagy

[58,59,60]

AT-101

Activate BNIP3, BNIP3L and HMOX1

[61]

THPN

TR3 translocation to mitochondrial gap change membrane potential

[62]

C₁₈-Pyr-Cer

Activate CerS1/C₁₈-Drp1

[64]

HPV

HPV E7-E2F5-Drp1-ceramide

[69]

Inhibition of FLT3-ITD

Activate Drp1-ceramide

[70]

Tat-Beclin

Activates Na⁺-K⁺ATPase

Autosis

[72]

Ischemia/Reperfusion

Activates Tfeb and inhibits Rubicon

[74, 75]

Tat-Beclin

Beclin1 binds to Na + -K + ATPase

[78]

Homocysteine and copper

Activates p22^phox and NOX-mediated p62 upregulation

[80]