Fig. 4: PI3K/mTOR inhibitors increased the anti-tumor effect of IR in H446RR cells. | Cell Death & Disease

Fig. 4: PI3K/mTOR inhibitors increased the anti-tumor effect of IR in H446RR cells.

From: PI3K/mTOR inhibitors promote G6PD autophagic degradation and exacerbate oxidative stress damage to radiosensitize small cell lung cancer

Fig. 4

A The cell proliferation of cells across various groups were determined by CCK8 assay at 72 h after 6 Gy of X-ray irradiation. B The expression of PARP and Cleaved-PARP across various groups were determined by immunoblotting. C, D The apoptosis of H446RR cells in different groups were detected by Annexin V/PI staining. E, F The growth of H446RR cells in different groups were detected using Giemsa stain, although H446RR cells typically failed to form colonies when a single cell existed. G, H The migration of H446RR cells across various treatments were determined at 8 h, 12 h and 24 h by wound healing assay.

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