Fig. 7: Working model of PYCR1-synthesized proline highlights breast cancer stemness under psychological stress. | Cell Death & Disease

Fig. 7: Working model of PYCR1-synthesized proline highlights breast cancer stemness under psychological stress.

From: Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress

Fig. 7

PYCR1-synthesized proline activates the cGMP-PKG signaling pathway to enhance TNBC stem-like properties under psychological stress. Targeting PYCR1-enhanced proline metabolic signaling provides a potential therapeutic approach for aggressive breast cancer patients undergoing psychological stress.

Back to article page