Fig. 6: mPGES-2 inhibitor SZ0232 affords protection against cisplatin-induced AKI. | Cell Death & Disease

Fig. 6: mPGES-2 inhibitor SZ0232 affords protection against cisplatin-induced AKI.

From: Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53

Fig. 6

C57BL/6 J mice were administered either SZ0232 (1 mg/kg) or saline once a day for 7 days, and followed by cisplatin-mediated model induction on day 4. Mice were sacrificed after cisplatin exposure for 72 h. Blood and tissues were collected for subsequent analysis. A SCr level, n = 6. B BUN level, n = 6. C Representative images of H&E and quantification of tubular injury score, n = 6. Scale bars = 20 μm. D GSH levels, n = 6. E MDA content, n = 6. F TUNEL staining and quantification, n = 6. Scale bars = 20 μm. G PGE2 level in the kidney after SZ0232 treatment, n = 6. Data are expressed as mean ± SEM. Statistical significance was assessed using a two-tailed unpaired Student’s t-test. Exact P values are indicated.

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