Fig. 2: Epigenetic changes in the course of adipogenic differentiation. | Cell Death & Disease

Fig. 2: Epigenetic changes in the course of adipogenic differentiation.

From: Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties

Fig. 2: Epigenetic changes in the course of adipogenic differentiation.

Adipogenesis occurs in a two-step process, namely the determination phase, followed by the differentiation phase. Adipogenic differentiation induction attracts CCAAT/enhancer-binding proteins beta and delta (C/EBPβ and C/EBPδ, respectively) activation and binding to peroxisome proliferator-activated receptor gamma (PPARG) promoter encoding PPARγ Simultaneously HDAC1 activity is decreased, which in turn activates the transcription of C/EBPα. C/EBPα and PPARγ are the major transcription factors whose expression is controlled by the acetylation (ac) of histone H3 lysine 9 and 27 (H3K9ac mark and H3K27ac mark, respectively). Further, di-methylation of histone H3 lysine 4 (H3K4me2 mark) upregulates adiponectin (apM1), glucose transporter type 4 (glut4), g-patch domain protein 1 (gdp1), and leptin (lep) gene expression. Created with BioRender.com.

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