Table 1 Relationship between USP4 expression and tumor characteristics in patients with ESCC.
Clinicopathologic features | Cases | USP4 expression | x2 | P value | |
|---|---|---|---|---|---|
Low | High | ||||
Gender | 1.165 | 0.281 | |||
Male | 146 | 46 (31.5%) | 100 (68.5%) | ||
Female | 32 | 7 (21.9%) | 25 (78.1%) | ||
Age (years) | 1.166 | 0.280 | |||
≤68 | 83 | 28 (33.7%) | 55 (66.3%) | ||
>68 | 95 | 25 (26.3%) | 70 (73.7%) | ||
Smoking history | 2.003 | 0.157 | |||
Yes | 121 | 32 (26.4%) | 89 (73.6%) | ||
None | 57 | 21 (36.8%) | 36 (63.2%) | ||
Tumor location | 0.641 | 0.726 | |||
Upper | 7 | 2 (28.6%) | 5 (71.4%) | ||
Middle | 149 | 46 (30.9%) | 103 (69.1%) | ||
Lower | 22 | 5 (22.7%) | 17 (77.3%) | ||
Tumor size (cm) | 5.368 | 0.021 | |||
<3.5 | 74 | 29 (39.2%) | 45 (60.8%) | ||
≥3.5 | 104 | 24 (23.1%) | 80 (76.9%) | ||
Histological type | 1.297 | 0.523 | |||
G1 | 9 | 3 (33.3%) | 6 (66.7%) | ||
G2 | 133 | 42 (31.6%) | 91 (68.4%) | ||
G3 | 36 | 8 (22.2%) | 28 (77.8%) | ||
Invasion depth | 7.118 | 0.028 | |||
pT1–2 | 30 | 15 (50.0%) | 15 (50.0%) | ||
pT3 | 96 | 24 (25.0%) | 72 (75.0%) | ||
pT4 | 52 | 14 (26.9%) | 38 (73.1%) | ||
Lymph node metastasis | 5.713 | 0.017 | |||
No | 107 | 39 (36.4%) | 68 (63.6%) | ||
Yes | 71 | 14 (19.7%) | 57 (80.3%) | ||
TNM staging | 2.571 | 0.109 | |||
I–II | 68 | 25 (36.8%) | 43 (63.2%) | ||
III | 110 | 28 (25.5%) | 82 (74.5%) | ||
