Fig. 2: VSMCs dedifferentiated to macrophage-like switching phenotype. | Cell Death & Disease

Fig. 2: VSMCs dedifferentiated to macrophage-like switching phenotype.

From: Inhibition of PDGFRβ alleviates endothelial cell apoptotic injury caused by DRP-1 overexpression and mitochondria fusion failure after mitophagy

Fig. 2: VSMCs dedifferentiated to macrophage-like switching phenotype.The alternative text for this image may have been generated using AI.

A Representative immunofluorescence images for detecting α-SMA (red), DAPI (blue) (n = 5 per group). Scale bar: 50 μm. B α-SMA fluorescence intensity. C Representative immunofluorescence images for double-labeling of OPN (green) and PDGFRβ (magenta) of aorta, DAPI (blue) (n = 5 per group). Scale bar: 50 μm. D OPN and PDGFRβ fluorescence intensity. E Representative immunofluorescence images for double-labeling of α-SMA (green) and MOMA (magenta) expressions of aorta, DAPI (blue) (n = 5 per group). Scale bar: 50 μm (low magnification) and 20 μm (high magnification). F α-SMA and MOMA fluorescence intensity. G Representative immunofluorescence images for double-labeling of αSMA (green) and F4/80 (red) expressions of aorta, DAPI (blue) (n = 5 per group). Scale bar: 50 μm (low magnification) and 20 μm (high magnification). H α-SMA and F4/80 fluorescence intensity. One-way ANOVA was followed by post hoc Tukey’s test. All results are presented as mean ± SEM. **P < 0.01,***P < 0.001 vs vehicle group, #P < 0.05, ##P < 0.01, ###P < 0.001, vs model group.

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