Fig. 4: Elevating the full-length transcript of ACSL3 increased the arachidonic acid content and erastin-ferrop sensitivity. | Cell Death & Disease

Fig. 4: Elevating the full-length transcript of ACSL3 increased the arachidonic acid content and erastin-ferrop sensitivity.

From: The BRD4-SRPK2-SRSF2 signal modulates the splicing efficiency of ACSL3 pre-mRNA and influences erastin-induced ferroptosis in osteosarcoma cells

Fig. 4

A Relative mRNA levels detected by RT-qPCR. “△“ means absence. B Relative protein levels detected by western blotting. C Abundance analysis of intracellular stearic acid, palmitic acid, double high -γ -linoleic acid and arachidonic acid by targeting fatty acid metabolomics. D Cell survival rate. Intracellular content of MDA (E), Fe2+ (F), and lipid ROS (G). Dunnett’s test of one-way ANOVA, *: P < 0.05; **: P < 0.01; ***: P < 0.005; n.s.: no significant.

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