Fig. 2: Phenotypic consequences of MAFB ectopic expression in human AML cell lines. | Cell Death & Disease

Fig. 2: Phenotypic consequences of MAFB ectopic expression in human AML cell lines.

From: Reversal of MYB-dependent suppression of MAFB expression overrides leukaemia phenotype in MLL-rearranged AML

Fig. 2

A Bar plot showing MAFB transcript qPCR quantification in complex karyotype (left) and MLL-rearranged (right) cell lines 48 h post doxycycline induction. B Line plot representing cell viability determined by counting cells every day for 96 h on constitutive doxycycline administration. The shaded lines incorporate the standard deviation. Statistical analysis was calculated using Student’s t test. (***p < 0.001). C Two-dimensional dot plot showing the analysis of CD11b and CD14 myeloid surface marker expression in all cell lines 96 h after ectopic MAFB expression. The percentage of double positive cells is indicated in each plot. Results are representative of 3 independent experiments. D Boxplot representing the percentage of myeloid cells generated upon MAFB overexpression in all cell lines. Control cells are indicated in blue while the red boxplot represent cells lines in which MAFB was ectopically expressed.

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