Fig. 3: SOAT1 regulates susceptibility to ferroptosis by SLC4OA1. | Cell Death & Disease

Fig. 3: SOAT1 regulates susceptibility to ferroptosis by SLC4OA1.

From: Ferroptosis sensitization in glioma: exploring the regulatory mechanism of SOAT1 and its therapeutic implications

Fig. 3

A qPCR array analyzed the downstream ferroptosis-related regulatory targets of SOAT1. Heat map showed the changes of all 87 ferroptosis-related genes. B Volcano map showed that SLC40A1 and CDO1 were the most related genes based on fold change and p value. C–E Cell death upon erastin, RSL3, and FIN56 treatment in U-87MG SOAT1 knockout cells estimated by CCK-8. F, G Cell death upon erastin when treating with DFO or tocopherol estimated by CCK-8. H, I Divided U-87MG cells into four groups to detect SLC40A1 and SOAT1 gene expressions and further measure intracellular free iron concentrations. Data significance is denoted as follows: *p < 0.05; **p < 0.01.

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