Fig. 1: NINJ1 regulates plasma membrane permeabilization during secondary necrosis, ferroptosis, parthanatos, cuproptosis and H2O2-induced necrosis, but not necroptosis. | Cell Death & Disease

Fig. 1: NINJ1 regulates plasma membrane permeabilization during secondary necrosis, ferroptosis, parthanatos, cuproptosis and H2O2-induced necrosis, but not necroptosis.

From: NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Fig. 1: NINJ1 regulates plasma membrane permeabilization during secondary necrosis, ferroptosis, parthanatos, cuproptosis and H2O2-induced necrosis, but not necroptosis.The alternative text for this image may have been generated using AI.

Wild-type and Ninj1 KO MEFs (A–L, Q–S) and RAW264.7 murine macrophage-like cells (M–P, T, U) were stimulated with the indicated compounds. PMP was either measured in function of time by Sytox Green positivity (A, C, E, G, I, K, M–Q, S–U) or at the indicated timepoint by LDH release (B, D, F, H, J, L, R). Data in the graphs are presented as mean ± SEM of independent experiments (n = 3). Statistical significance was determined by two-way ANOVA for Sytox Green positivity or by an unpaired two-tailed T test for LDH release. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001.

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