Fig. 8: Graphical diagram of TACC3 knockdown inhibits tumor cell proliferation and migration, and increases chemosensitivity in pancreatic cancer. | Cell Death & Disease

Fig. 8: Graphical diagram of TACC3 knockdown inhibits tumor cell proliferation and migration, and increases chemosensitivity in pancreatic cancer.

From: Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer

Fig. 8: Graphical diagram of TACC3 knockdown inhibits tumor cell proliferation and migration, and increases chemosensitivity in pancreatic cancer.

TACC3 is a promoter of PDAC that promotes the cancer cell proliferation by regulating bipolar spindle formation and cell cycle progression, and promotes cell migration and chemoresistance as well. TACC3 physically interacts with, stabilizes and regulates its downstream protein KIF11, which establishes and maintains the spindle bipolarity by generating outward forces and contributes to microtubule flux. Knockdown of TACC3 and its downstream protein KIF11 leads to abnormal spindle formation and S phase arrest of the cell cycle, inhibiting cancer cell proliferation, and suppresses cancer cell migration and increases chemosensitivity in PDAC.

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