Fig. 4: Whole genome RNA sequencing and functional enrichment analysis. | Cell Death & Disease

Fig. 4: Whole genome RNA sequencing and functional enrichment analysis.

From: POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6

Fig. 4

A Whole genome RNA sequencing suggested that POU5F1 downstream genes TIRAP and TRIM59. B KEGG enrichment analysis suggested that POU5F1 downstream genes were related to TIRAP-dependent Toll-like receptor 4 signaling pathway. C GO enrichment analysis suggested that POU5F1 downstream genes were related to Toll-like receptor signaling pathway. D GEPIA 2 analysis suggested that POU5F1 negatively regulated TRIM59. E RT-qPCR was used to verify the sequencing results. F Western blot was used to verify the sequencing results. Unpaired t test was used to compare the data between two groups. *P < 0.05, **P < 0.01, ***P < 0.001.

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