Fig. 11: The proposed mechanism mediating the protective action of GPER1 against UUO-induced renal fibrosis.
From: Activation of GPER1 in macrophages ameliorates UUO-induced renal fibrosis
GPER1 agonist G-1 ameliorated UUO-induced renal fibrosis, possibly by inhibiting M0 to M1 and M0 to M2 macrophage polarization and attenuating immune response and fibrosis.
