Fig. 1: Effect of Ahr −/− MSC on GVHD treatment. | Cell Death & Disease

Fig. 1: Effect of Ahr −/− MSC on GVHD treatment.

From: The aryl hydrocarbon receptor controls mesenchymal stromal cell-mediated immunomodulation via ubiquitination of eukaryotic elongation factor-2 kinase

Fig. 1

A To induce GVHD, BALB/c mice were irradiated with a dose of 8.5 Gy. One day after irradiation, 5 × 106 bone marrow and 5 × 106 spleen cells from C57BL/6 mice were injected. On days 1, 3, and 5 after transplantation, PBS, 2 × 105 WT-, and KO-MSCs were injected intravenously to observe the therapeutic efficacy until 35 days. Bone marrow was injected as a negative control, naïve group (n = 5). PBS (n = 10), WT-MSCs (n = 10), and KO-MSCs (n = 10) were injected into the induced GVHD mice. The weight changes (B) and survival rate (C) of the GVHD mice were examined over the experimental period. D The clinical scores were monitored according to the severity of symptoms such as ruffled hair, hunched back, diarrhea, damaged skin, and ascites.

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