Fig. 3: Apigenin regulates hnRNPA2 substrates. | Cell Death & Disease

Fig. 3: Apigenin regulates hnRNPA2 substrates.

From: Transcriptome reprogramming through alternative splicing triggered by apigenin drives cell death in triple-negative breast cancer

Fig. 3

A The enrichment of hnRNPA2, MSI2, and CELF1 substrates among the genes differentially spliced in MDA-MB-231 cells treated with 50 μM apigenin. Enrichment was evaluated by a hypergeometric distribution test. B–D The genes differentially spliced in cells treated with apigenin were segregated as hnRNPA2 (B), CELF1 (C), or MSI2 (D) substrates (yellow) or non-substrates (blue) to compare the cumulative fractions of ΔPSI. E Molecular functional enrichment of hnRNPA2 substrates altered by apigenin through AS using IPA. Statistical significance was evaluated by Kolmogorov–Smirnov (K–S) test for B–D and by Fisher’s exact test for E.

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