Fig. 3: Knockout of NEDD4 does not show cross-resistance to oxaliplatin and irinotecan-induced apoptosis. | Cell Death & Disease

Fig. 3: Knockout of NEDD4 does not show cross-resistance to oxaliplatin and irinotecan-induced apoptosis.

From: The E3 ubiquitin ligase NEDD4 regulates chemoresistance to 5-fluorouracil in colorectal cancer cells by altering JNK signalling

Fig. 3: Knockout of NEDD4 does not show cross-resistance to oxaliplatin and irinotecan-induced apoptosis.The alternative text for this image may have been generated using AI.

FACS-based apoptosis was performed on LIM1215 WT and NEDD4 KO cells treated with or without chemotherapeutic drug A oxaliplatin (n = 4) (0.5, 1 and 2 µM) and B irinotecan (n = 3) (25 and 50 µM) for 72 h. Percentage of cell death is represented as percent sub-G1. C, D Oxaliplatin and irinotecan-treated WT and NEDD4 KO LIM1215 cells, respectively, were analysed for cell cycle profile. All data are represented as mean ± SEM.

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