Fig. 2: Hepatic stellate cell specific deletion of BRG1 attenuates liver fibrosis in mice.
From: The chromatin remodeling protein BRG1 regulates HSC-myofibroblast differentiation and liver fibrosis
A–F 8-week male Smarca4f/f; Lrat-Cre mice and Smarca4f/f mice were subjected to CCl4 injection for 4 wk. Plasma ALT (A) and AST (B) levels. Expression levels of pro-fibrogenic genes were examined by qPCR (C) and Western blotting (D). Picrosirius red and Masson’s trichrome staining (E). Hydroxylproline quantification (F). G–L 8-week male Smarca4f/f; Lrat-Cre and Smarca4f/f mice were subjected to BDL for 2 wk. Plasma ALT (G) and AST (H) levels. Expression levels of pro-fibrogenic genes were examined by qPCR (I) and Western blotting (J). Picrosirius red and Masson’s trichrome staining (K). Hydroxylproline quantification (L). N = 4–8 mice for each group. Data are expressed as the means ± SD. *p < 0.05.
