Fig. 6: Relation between ARRB2 and MAPK signaling in prostate cancer. | Cell Death & Disease

Fig. 6: Relation between ARRB2 and MAPK signaling in prostate cancer.

From: PRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling

Fig. 6

A Protein interaction networks of ARRB2 in String database. B Gene Set Enrichment Analysis (GSEA) of ARRB2 in TCGA-PRAD database. C Effect of ARRB2 knockdown (siARRB2) on phosphorylation of ERK1/2 (pERK1/2). D Immunofluorescence (IF) staining of ERK1/2 and Flag in 22Rv1 cells with ARRB2 overexpression (FLAG-tag). E Co-Immunoprecipitation test with anti-ARRB2 and anti-ERK1/2 in 22Rv1 cells. F Immunohistochemical (IHC) staining of pSTAT5B, ARRB2 and pERK1/2 in prostate tissues including castration resistant prostate cancer(CRPC), hormone naive prostate cancer (HNPC) and benign prostate hyperplasia (BPH), and the comparison of ARRB2 and pERK1/2 expression levels in different pathological tissues. G Correlation between the expression levels of pSTAT5B, ARRB2, and pERK1/2 in CRPC tumor tissues. H IHC score of pSTAT5B, ARRB2, and pERK1/2 in CRPC tumor tissues.

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