Fig. 6: The resolution of LCMV acute infection is associated to CTL-mediated spleen fibrosis. | Cell Death & Disease

Fig. 6: The resolution of LCMV acute infection is associated to CTL-mediated spleen fibrosis.

From: Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation

Fig. 6

a Schematic representation of anti-IFNAR (aIFNAR) and anti-CD8α (aCD8) antibody treatments in acutely LCMV-infected WT mice. Spleen fibrosis score (b) and representative images of Masson’s Trichrome Stained spleen sections (c) used to score the fibrosis in each group on days 15 and 30 post-infection; the black arrows indicate deposits of collagen fibers (in blue – Masson trichrome stain) characteristic of fibrosis. Data shown are the mean of n = 6 to 9 mice. ****p ≤ 0.0001; unpaired two-tailed t-test.

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