Fig. 4: FAM83F regulated cell proliferation and glycolysis through the Wnt/β-catenin signaling pathway. | Cell Death & Disease

Fig. 4: FAM83F regulated cell proliferation and glycolysis through the Wnt/β-catenin signaling pathway.

From: Upregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/β-catenin signaling activation

Fig. 4

A Gene Set Enrichment Analysis (GSEA) demonstrated that the Wnt/β-catenin signaling pathway was more correlated with patients with high FAM83F expression than patients with low FAM83F expression. NES, normalized enrichment score. B, C Western blotting was used to detect the protein levels of Wnt/β-catenin pathway-related factors and proapoptotic protein Bim under the influence of FAM83F overexpression or knockdown. FAM83F-overexpressing HeLa cells and their controls were treated in the absence or presence of the Wnt/β-catenin pathway inhibitor XAV939. Apoptosis (D), cell cycle progression (E), cell proliferation (F) and glycolysis capacity (G, H) were measured. The data represent the mean ± SD of three independent experiments, and the level of significance was indicated by ****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05. ns no significance (p > 0.05).

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