Fig. 1: Tumor-intrinsic Aurora-A has different effects on survival rate, which depend on immune cell infiltration. | Cell Death & Disease

Fig. 1: Tumor-intrinsic Aurora-A has different effects on survival rate, which depend on immune cell infiltration.

From: Neutralizing IL-16 enhances the efficacy of targeting Aurora-A therapy in colorectal cancer with high lymphocyte infiltration through restoring anti-tumor immunity

Fig. 1

A The overall survival rates of colon adenocarcinoma cancer (COAD) patients from the TCGA cohort were analyzed by high (red) and low (blue) expressions of Aurora-A with low (left) or high (right) immune scores in CRC. Immune scores in the TCGA COAD dataset were analyzed by xCell. KM-plot is used for statistical analysis. *, p-value < 0.05; ns, no significance. B−E CRC patients from the NCKUH cohort were enrolled for analysis. CRC patients were divided into mild, moderate, and severe lymphatic infiltration groups based on the percentage of tumor-infiltrating lymphocytes according to the H&E staining (B). The percentage of tumor-infiltrating lymphocytes in high and low Aurora-A (AURKA) expressed CRC is shown (C). The overall survival rates of CRC patients in severe (red), moderate (orange), and mild (blue) tumor-infiltrating lymphocytes with low (left) or high (right) tumor-intrinsic Aurora-A (AURKA) expression are shown. KM-plot is used for statistical analysis (D). **, p-value < 0.01. The overall survival rates of CRC patients with high (red) and low (blue) expression of Aurora-A (AURKA) in CRC patients having mild, moderate, or severe lymphocyte infiltration are shown. KM-plot is used for statistical analysis (E). *, p-value < 0.05. F Using the TCGA COAD dataset, patients are delineated into groups having either high (blue) or low (red) expression levels of Aurora-A (AURKA). The immune response signaling pathway was analyzed by gene set enrichment analysis (GSEA).

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