Fig. 2: Sohlh2 in M2 macrophage promotes the oncogenic properties of TNBC cells in vitro. | Cell Death & Disease

Fig. 2: Sohlh2 in M2 macrophage promotes the oncogenic properties of TNBC cells in vitro.

From: TRIM21-mediated Sohlh2 ubiquitination suppresses M2 macrophage polarization and progression of triple-negative breast cancer

Fig. 2

A Scheme of the workflow illustrating that M2 macrophage co-cultured with TNBC cells in Transwell chambers. The MDA-MB-231 and 4T1.2 cell growth rates were evaluated with CCK8 (B) and EdU (C) assays. Migration (D) and Invasion ability (E) were performed in MDA-MB-231 or 4T1.2 cells co-cultured with M2 macrophages by Transwell assays. F EMT-related markers in MDA-MB-231 or 4T1.2 cells co-cultured with M2 macrophages were detected by western blot analysis. Scale bar indicates 50 μm. The values indicate the mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.

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