Fig. 4: Infiltration of tumorigenic CAFs in the tumor microenvironment of AEG. | Cell Death & Disease

Fig. 4: Infiltration of tumorigenic CAFs in the tumor microenvironment of AEG.

From: Comparative single-cell analysis reveals heterogeneous immune landscapes in adenocarcinoma of the esophagogastric junction and gastric adenocarcinoma

Fig. 4

A Representative images of immunohistochemistry staining showing the protein expression of COL1A1 in AEG tumors. B UMAP plot for two cell clusters of CAFs. C Expression of marker genes to identify iCAF and myCAF. D Heatmap showing the differential expressed genes between iCAF and myCAF. E Distinct enrichment of signaling pathways between iCAF and myCAF. F Survival curves of patients stratified according to the expression of COL1A1 or signatures of two CAF subclusters. Survival was measured using the Kaplan-Meier method and P values were calculated using log-rank test.

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