Fig. 1: Innate immune response interconnection with AR signaling in blood from individuals with CAIS and in dysgenic gonads. | Cell Death & Disease

Fig. 1: Innate immune response interconnection with AR signaling in blood from individuals with CAIS and in dysgenic gonads.

From: Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans

Fig. 1

Whole proteome analysis of leukocytes from blood of individuals with CAIS with GO for innate immune response (a), GO for inflammation (b) and GO for AR signaling (c). Immunoblotting for AR protein in blood samples of the control (d) and CAIS (e) groups and its quantification (f). Actin was used as the loading control. Immunoblotting for AR protein in gonadal tissue samples from the control (g), CAIS (h), Swyer (i) and DSD-GCT (j) groups. Quantification of fAR (k) and ARv7 (l) relative protein levels of the immunoblots (g–j). ANOVA and unpaired t test were used for statistical analysis; p values, means and standard deviations are shown on the plots.

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