Fig. 7: High tumor PANX1 expression and wild-type P2RX7 expression were associated with high infiltration of cytotoxic T lymphocytes and favorable survival outcomes in CRC patients who received adjuvant chemotherapy. | Cell Death & Disease

Fig. 7: High tumor PANX1 expression and wild-type P2RX7 expression were associated with high infiltration of cytotoxic T lymphocytes and favorable survival outcomes in CRC patients who received adjuvant chemotherapy.

From: TNFα modulates PANX1 activation to promote ATP release and enhance P2RX7-mediated antitumor immune responses after chemotherapy in colorectal cancer

Fig. 7: High tumor PANX1 expression and wild-type P2RX7 expression were associated with high infiltration of cytotoxic T lymphocytes and favorable survival outcomes in CRC patients who received adjuvant chemotherapy.

A The P2RX7-E496A allele was associated with survival outcomes in stage III COAD patients who received adjuvant chemotherapy (n = 409, log-rank p = 0.016). B P2RX7 variant expression was significantly associated with the infiltration of cytotoxic CD8+ TILs (unpaired t test, p = 0.04). C Patients expressing wild-type P2RX7 and with high infiltration of CD8+ immune cells had favorable survival outcomes (n = 256, log-rank, p = 0.0107). D Mutant P2RX7 expression and high infiltration of CD8+ immune cells were not associated with survival outcome (n = 231, log-rank, p = 0.231). E Multivariate Cox analysis showed that P2RX7 is an independent prognostic factor for stage III COAD patients who received adjuvant chemotherapy (HR = 1.47, 95% CI = 1.08–1.99, p = 0.014). F The proposed mechanism by which TNFα-mediated PANX1 cleavage promotes ATP release to trigger P2RX7-dependent dendritic cell activation and enhance antitumor immunity following immunogenic chemotherapy in colorectal cancer.

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