Fig. 5: POLE P286R mutation regulates the DSB repair pathway. | Cell Death & Disease

Fig. 5: POLE P286R mutation regulates the DSB repair pathway.

From: The P286R mutation of DNA polymerase ε activates cancer-cell-intrinsic immunity and suppresses endometrial tumorigenesis via the cGAS-STING pathway

Fig. 5

A Heatmap analyses of gene expression profiles in human EC specimens with WT or mutant POLE. B GSEA of the EMT gene set in the EC cells with P286R mutation or WT POLE. The hallmark EMT genes were obtained from the Molecular Signatures Database. C KEGG pathway analysis of the EMT gene set in EC cells with P286R mutation or WT POLE. D GO analyses of the differentially expressed genes in human EC samples with POLE mutations or WT POLE. E GO analyses of the differentially expressed genes in human EC samples with POLE mutations or WT POLE. F Relative scores of the predicated interaction proteins in human EC cells with POLE mutations. G Western blot analyses of repair-related proteins in human EC cells and mutant POLE cells without or with Etoposide treatment. H Western blot analyses of repair-related proteins in human EC cells and mutant POLE cells without or with Etoposide treatment.

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