Fig. 5: FKBP10 promotes ccRCC proliferation and metastasis in vivo depending on its PPlase activity. | Cell Death & Disease

Fig. 5: FKBP10 promotes ccRCC proliferation and metastasis in vivo depending on its PPlase activity.

From: FKBP10 promotes clear cell renal cell carcinoma progression and regulates sensitivity to the HIF2α blockade by facilitating LDHA phosphorylation

Fig. 5: FKBP10 promotes ccRCC proliferation and metastasis in vivo depending on its PPlase activity.The alternative text for this image may have been generated using AI.

A FKBP10 regulated LDHA phosphorylation depending on its PPlase activity. B Nondenaturing protein electrophoresis analysis of His-tagged LDHA in 786 O cells transfected as indicated. C ECAR analysis of 786 O cells in (A). D, E Bioluminescence pictures of renal orthotopic tumors and quantitation of bioluminescence data are shown. F,G Gross appearance of the tumors and statistical analysis of tumor weights are shown. H Representative HE and IHC staining of tumors in the tested mice. Scale bar: 100 µm. I, J Bioluminescence pictures of lung metastases and quantitation of bioluminescence data are shown. K, L Gross appearance of the lung tissues analyzed by HE staining. Microscopic metastatic foci in the lung were counted. Arrows indicate pulmonary metastatic nodules. Scale bar: 100 µm. Statistical analyses were performed with a two-tailed unpaired Student’s t test (NS, P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001).

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