Fig. 1: Hepatic POLB responses to peripheral clocks and food signals. | Cell Death & Disease

Fig. 1: Hepatic POLB responses to peripheral clocks and food signals.

From: DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1

Fig. 1

RT-qPCR (A) and Western blot (B) analyses of POLB expression in the liver of mice that were fed ad libitum and subjected to ZT. **P < 0.01, peak vs. nadir, one-way ANOVA followed by Bonferroni’s posthoc test, n = 5. RT-qPCR (C) and Western blot (D) analyses of POLB expression in the liver of mice subjected to 16-h fasting or 16-h fasting, followed by 20-h refeeding. **P < 0.01 vs. fasted 16 h group, one-way ANOVA followed by Bonferroni’s posthoc test, n = 5. RT-qPCR (E) and Western blot (F) analyses of POLB expression in the liver of mice subjected to time-restricted feeding. The fold changes were calculated by normalizing the raw data to ZT0 NF group. **P < 0.01 NF12 vs. NF0, ##P < 0.01 DF12 vs. DF0, one-way ANOVA followed by Bonferroni’s posthoc test, n = 5. NF night feeding, DF day feeding.

Back to article page