Table 1 Peli1 deficiency ameliorates TAC-induced cardiac dysfunction.

From: HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy

Groups

WT Sham

WT TAC

Peli1KO Sham

Peli1KO TAC

n

12

14

6

10

EF (%)

61.540 ± 2.793

43.516 ± 8.818***

60.365 ± 3.096

54.257 ± 2.690###

FS (%)

32.321 ± 1.843

24.265 ± 5.236***

31.630 ± 2.046

28.046 ± 1.455#

Ivs;d (mm)

0.710 ± 0.024

0.994 ± 0.133***

0.731 ± 0.043

0.914 ± 0.070#

Ivs;s (mm)

1.141 ± 0.072

1.349 ± 0.143***

1.146 ± 0.092

1.279 ± 0.092 p = 0.19

LVID;d (mm)

3.562 ± 0.187

3.980 ± 0.396**

3.745 ± 0.229

3.873 ± 0.238#

LVID;s (mm)

2.413 ± 0.185

3.028 ± 0.184***

2.563 ± 0.220

2.831 ± 0.223#

LVPW;d (mm)

0.734 ± 0.401

1.057 ± 0.174***

0.758 ± 0.031

0.968 ± 0.113#

LVPW;s (mm)

1.193 ± 0.070

1.415 ± 0.163***

1.206 ± 0.072

1.332 ± 0.089#

  1. Cardiac function was measured by echocardiography at 4 weeks after TAC. Data are shown as mean ± SD. Statistical analysis was performed with one-way ANOVA followed by Tukey’s test.
  2. **p < 0.01; ***p < 0.001 vs WT Sham group.
  3. #p < 0.05; ###p < 0.001; p = 0.19 (not significant) vs WT TAC group.
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