Table 2 HNF4α antagonist BI6015 inhibits the ameliorative effect of Peli1 knockout on TAC-induced cardiac dysfunction.

From: HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy

Groups

WT TAC

Peli1KO TAC

Peli1KO TAC + DMSO

Peli1KO TAC + BI6015

n

6

6

6

6

EF (%)

41.325 ± 3.335

53.623 ± 3.422***

53.175 ± 3.861

45.162 ± 2.907##

FS (%)

20.063 ± 1.798

27.257 ± 2.221***

27.025 ± 2.545

22.197 ± 1.599##

Ivs;d (mm)

1.013 ± 0.068

0.751 ± 0.107**

0.767 ± 0.130

0.981 ± 0.135#

Ivs;s (mm)

1.330 ± 0.049

1.076 ± 0.089**

1.104 ± 0.0169

1.320 ± 0.147#

LVID;d (mm)

4.326 ± 0.278

3.678 ± 0.288**

3.789 ± 0.234

4.169 ± 0.286#

LVID;s (mm)

3.461 ± 0.279

2.675 ± 0.216***

2.764 ± 0.183

3.246 ± 0.275##

LVPW;d (mm)

1.094 ± 0.156

0.778 ± 0.137*

0.795 ± 0.195

1.055 ± 0.131#

LVPW;s (mm)

1.200 ± 0.283

1.232 ± 0.289

1.204 ± 0.282

1.193 ± 0.151#

  1. Cardiac function was measured by echocardiography at 4 weeks after TAC. Data are shown as mean ± SD. Statistical analysis was performed with one-way ANOVA followed by Tukey’s test.
  2. *p < 0.05; **p < 0.01; ***p < 0.001 vs WT TAC group.
  3. #p < 0.05; ##p < 0.01 vs Peli1KO TAC group.
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