Fig. 3: Lack of necroptosis pathways does not affect age-related disease severity or response to re-challenge. | Cell Death & Disease

Fig. 3: Lack of necroptosis pathways does not affect age-related disease severity or response to re-challenge.

From: Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo

Fig. 3

A, B Aged C57BL/6 and Mlkl−/− mice (6–8 months) were intranasally inoculated with 104 TCID50 SARS-CoV-2 P21 and monitored for A the proportion of mice that became moribund, reaching humane endpoint and B daily percentual weight change over time, relative to the initial weight. (n = 6–8 mice per group; Data is representative of 2 independent experiments) C, B Mock or P21-infected C57BL/6 and Mlkl−/− mice were rechallenged 28 days later with P21 and analyzed 3 days post re-challenge for C lung viral load (TCID50) and D percent weight change, compared to weight before second infection (n = 4 mice per group; Data are representative of 2 independent experiments). One-way ANOVA with multiple comparisons (D), after log10 transformation (C) was performed. Mean ± SD are shown. ***p < 0.001, ****p < 0.0001.

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