Fig. 2: CRCs express high basal expression of BCL-XL and MCL-1.
From: BCL-XL inhibitors enhance the apoptotic efficacy of BRAF inhibitors in BRAFV600E colorectal cancer
A Basal mRNA expression levels of pro-survival genes in human CRCs. Data obtained from the COAD cohort profiled by the cancer genome atlas (TCGA)(n = 266). B Basal mRNA expression of pro-survival genes in CRC cell lines. mRNA expression was extracted from n = 58 CRC cell lines profiled by RNA-seq analysis as previously reported [29]. C Relative mRNA expression of pro-survival genes in primary BRAFWT versus BRAFV600E CRCs. Data obtained from the TCGA COAD cohort (WT, n = 236, BRAF-mutant, n = 30). D Relative mRNA expression of pro-survival genes in BRAFWT versus BRAFV600E CRC cell lines. mRNA expression was extracted from n = 47 BRAFWT and n = 11 BRAFV600E CRC cell lines profiled by RNA-seq analysis by [29].
