Fig. 1: Prognostic significance of m6A regulators in human TCGA-LGG. | Cell Death & Disease

Fig. 1: Prognostic significance of m6A regulators in human TCGA-LGG.

From: Depletion of the N6-Methyladenosine (m6A) reader protein IGF2BP3 induces ferroptosis in glioma by modulating the expression of GPX4

Fig. 1

A Survival map showing correlation of expression of 22 m6A regulators with survival time in TCGA-LGG. The red and blue colors indicate poor and favorable prognosis, respectively, with the color intensity corresponding to the magnitude of hazard ratio (HR). A bounding box around tiles shows statistical significance (p < 0.05). B KM curves showing overall survival for TCGA-LGG patients with high and low expression of ZCCHC4, RBM15, IGF2BP2, IGF2BP3, YTHDC2, YTHDF2, HNRNPA2B1, and ALKBH5. C Expression distribution of IGF2BP3 between tumor and normal tissues in TCGA-LGG patients. D Expression distribution of IGF2BP3 in different grades of TCGA-LGG and TCGA-GBM patients. E Expression distribution of IGF2BP3 in IDH-mutant or IDH-wildtype TCGA-LGG patients. F Expression distribution IGF2BP3 in 1p/19q codeletion or 1p/19q non-codeletion TCGA-LGG patients. Statistical significance levels are indicated as follows: *, p < 0.05; **, p < 0.01; ***, p < 0.001.

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