Fig. 5: Knocking out GITRL in liver progenitor cells promoted hepatocyte repopulation. | Cell Death & Disease

Fig. 5: Knocking out GITRL in liver progenitor cells promoted hepatocyte repopulation.

From: GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR+CD8+ T lymphocytes in CDE Mice

Fig. 5: Knocking out GITRL in liver progenitor cells promoted hepatocyte repopulation.

A Experimental design strategy of Sox9Cre-ERRosaTdTomatoTnfsf18flox/flox mice given a single dose of tamoxifen to inactivate GITRL and activate TdTomato followed by CDE injury after 2 weeks of tamoxifen washout. B Representative whole-slide scans of liver sections for TdTomato from the CDE-exposed Sox9Cre-ERRosaTdTomatoTnfsf18+/+ mice or Sox9Cre-ERRosaTdTomatoTnfsf18+/+ mice and their control mice. C Representative immunofluorescence images of TdTomato, GITRL and DAPI. D Representative immunofluorescence images of TdTomato, DAPI and CK19 or HNF4α. Statistical quantifications of the percentage of TdTomato+CK19+ cells among CK19+ cells or TdTomato+HNF4α+ cells among HNF4α+ cells.

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