Fig. 7: GITR and GITRL participate in the interaction of CD8+ T lymphocytes and liver progenitor organoids. | Cell Death & Disease

Fig. 7: GITR and GITRL participate in the interaction of CD8+ T lymphocytes and liver progenitor organoids.

From: GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR+CD8+ T lymphocytes in CDE Mice

Fig. 7: GITR and GITRL participate in the interaction of CD8+ T lymphocytes and liver progenitor organoids.

A Representative flow cytometry images of the proportion of CD8+ T lymphocytes before and after magnetic sorting from the nonparenchymal cells. B Experimental design strategy of the coculture system of CD8+ T lymphocytes and liver progenitor organoids. C The mRNA transcript levels of EpCAM, Sox9, ALB, HNF4α, Axin1, and Fzd1 in liver progenitor organoids cocultured with CD8+ T lymphocytes with or without GITR antibodies. D The mRNA transcript levels of TNFα and TGF-β2 in CD8+ T lymphocytes cocultured with Sox9Cre-ERRosaTdTomatoTnfsf18+/+ or Sox9Cre-ERRosaTdTomatoTnfsf18flox/flox liver progenitor organoids. E Schematic representation of the effect of GITR and GITRL on hepatic progenitor cells and CD8+ T lymphocytes in CDE mice.

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