Fig. 9: Ruxo inhibited the growth of mice xenografts in vivo. | Cell Death & Disease

Fig. 9: Ruxo inhibited the growth of mice xenografts in vivo.

From: Ruxolitinib induces apoptosis and pyroptosis of anaplastic thyroid cancer via the transcriptional inhibition of DRP1-mediated mitochondrial fission

Fig. 9

A Schematic diagram of animal experiments. B Tumor volumes were measured every other day, growth curves of tumors treated with Ruxo (0, 15 and 30 mg/kg, intraperitoneal injection) (n = 6/group) were analyzed by GraphPad Prism 9 software. Data are shown as mean ± SD. C, D Bar charts showed average tumor weights and body weights of each group. Data are shown as mean ± SD (n = 6). E Representative gross image of tumors at the endpoint of the experiment. F HE staining and Ki67 by IHC staining assay was performed of each group. G JAK1, p-JAK1, p-STAT3, DRP1, c-PARP, c-caspase 3, expression levels in tumors as measured by IHC staining assay. Values are presented as mean ± SD for n = 3, analyzed by one-way ANOVA using the Holm-Sidak method (B-D). *p < 0. 05, **p < 0. 01.

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