Fig. 1: Schematic diagram of the ERS and UPR pathways. | Cell Death & Disease

Fig. 1: Schematic diagram of the ERS and UPR pathways.

From: Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury

Fig. 1

Created with BioRender.com. ER endoplasmic reticulum, UPR unfolded protein response, PERK protein kinase RNA-like ER kinase, eIF2α eukaryotic translation initiation factor 2 alpha, p-eIF2α: phosphorylated eIF2α, ATF4 activating transcription factor 4, PP1 type 1 protein phosphatase, GADD34 growth arrest and DNA damage-inducible gene 34, IRE1 inositol-requiring protein 1, XBP-1 X box binding protein 1, XBP-1s spliced XBP-1, RIDD regulated IRE1α‑dependent decay, ATF6 activating transcription factor 6, ATF6f fragment of ATF6α, ERAD ER-associated degradation, GLS Golgi-localization signal, S1P site-1 protease, S2P site-2 protease.

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