Fig. 6: IGF2BP3 enhances the growth of CC tumor in vivo.
From: IGF2BP3 enhances lipid metabolism in cervical cancer by upregulating the expression of SCD
A, B Hela cells stably expressing shNC, shIGF2BP3, or shIGF2BP3+oe-SCD were subcutaneously injected into the right back of nude mice. Tumor images were captured using the PerkinElmer IVIS preclinical in vivo imaging system 20 days (A) and 30 days (B) after injection. C The tumor volumes were measured every two days from the 7th day after injection. D The weights of transplanted tumors were measured. E The tumor sections were stained by IHC with an antibody against Ki-67. Scale bar: 50 μm. F The tumor sections were stained by IHC with an antibody against SCD. Scale bar: 50 μm. G Kaplan–Meier survival curve presents the overall survival rate of mice in each group (n = 5, *P < 0.05 through the log-rank test). H A proposed modulatory mould for the function of IGF2BP3 in adipogenesis and tumorigenesis. Each value represents the mean ± SD (Student’s t test). *P < 0.05 and ****P < 0.0001.
