Table 2 IC50 values of NCK in immortalized pancreatic duct epithelial and PDAC cell lines.
Cell line | Oncogene | Tumor suppressor gene | NCK IC50 ± SD (μM) | |||||
|---|---|---|---|---|---|---|---|---|
KRAS | BRAF | TP53 | BRCA2 | CDKN2A | SMAD4 | |||
PDAC | SW1990 | ↑ G12D | ↓ | 0.91 ± 0.23 | ||||
Panc-1 | ↑ G12D | ↓ | ↓ | 1.96 ± 0.47 | ||||
AsPC-1 | ↑ G12D | ↓ | ↓ | ↓ | 2.20 ± 0.27 | |||
CFPac-1 | ↑ G12V | ↓ | ↓ | 2.17 ± 0.10 | ||||
Capan-1 | ↑ G12V | ↓ | 1.43 ± 0.17 | |||||
Capan-2 | ↑ G12V | 4.03 ± 0.61 | ||||||
BxPC-3 | ↑ | ↓ | ↓ | ↓ | 1.74 ± 0.18 | |||
Immortalized Normal | HPDE6-C7 | 64.36 ± 25.48 | ||||||
