Fig. 3: Erastin and RSL3 treatment led to increased SIRT3 protein expression during GBM cell ferroptosis. | Cell Death & Disease

Fig. 3: Erastin and RSL3 treatment led to increased SIRT3 protein expression during GBM cell ferroptosis.

From: Targeting SIRT3 sensitizes glioblastoma to ferroptosis by promoting mitophagy and inhibiting SLC7A11

Fig. 3: Erastin and RSL3 treatment led to increased SIRT3 protein expression during GBM cell ferroptosis.The alternative text for this image may have been generated using AI.

A Erastin and RSL3 treatment induced GBM cell death in a dose-dependent manner. B Erastin and RSL3 treatment induced typical ferroptosis-related morphology changes in mitochondria, as shown by transmission electron microscopy in GBM cells, including smaller mitochondria, higher density of the mitochondrial membrane, and reduced mitochondrial cristae numbers. C Erastin and RSL3 treatment increased expression of ferroptosis-related proteins in GBM cells. D Erastin and RSL3 treatment increased SIRT3 protein expression. E Erastin and RSL3 treatment did not affect SIRT3 mRNA expression. IRP1, iron regulatory protein 1; HO-1, heme oxygenase 1; TFR1, transferrin 1; SLC7A11, solute family 7 member 11.

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